What Science says about CBDA

      How CBDA Works, Unique Biological Activity

• Many cannabinoids (CBD,CBG,...) bind to CB1 or CB2 receptors, Cannabinoid receptors, located throughout the body (PMID:32629422). Instead,  CBDA modulates enzymes such as COX-2 which are involved in inflammatory pathways and inhibit their activities similar to how NSAIDs work at reducing pain and inflammation (PMID: 18556441).                                                                   

• CBDA also interacts with serotonin receptors, which are linked to mood regulation and nausea control (PMID:41056675). Because of these different pathways, CBDA can influence biological systems in ways CBD doesn’t, offering a complementary experience.​                                                                                                                

     Bioavailability & Absorption

• Research indicates that CBDA is absorbed much more efficiently than CBD in the body, potentially leading to much higher plasma levels (67x more) than CBD after oral dosing (PMID: 41017237).                                                                                                                                                        

• In a human study with full-spectrum hemp products, CBDA showed greater bioavailability and faster absorption compared with decarboxylated forms such as CBD (PMID: 40040421).                                                       

     CBDA vs CBD Potency (Preclinical Evidence)

• CBDA has up to 1000x greater potency at the 5-HT1A serotonin receptor compared with CBD in lab assays (PMD: 34916950).                                                                                                                                                                  

• CBDA exhibits effects at much lower doses than CBD in rodent models for nausea and related pathways ((PMID:41056675).                                                                                                                                                                                                                                                                                                   Support for Cognitive & Neurological Activity

• In preclinical models, CBDA demonstrated the ability to cross the blood-brain barrier and mitigate Alzheimer’s-like pathology, reducing markers such as amyloid-beta and tau proteins in mouse models (PMID: 37047798).                                                                                                                                                                                                                                                                                           Anticancer activity of CBDA

• CBDA may inhibit migration of aggressive cancer cells (e.g., breast cancer cell lines), indicating active biological effects independent of CBD (PMID:22963825).